What is NID

The term neuro-immune disease refers to a group of complex multisymptom diseases characterized by acquired dysregulation of both the immune system and the nervous system. These diseases most often follow an infectious or flu-like illness and may result in lifelong disease and disability. Included in this definition are similarly presenting illnesses such as ME, CFS, fibromyalgia, post-Lyme disease, Gulf War illness and some cases of autism spectrum disorder.

  1. 1 in 300 suffers from myalgic encephalomyelitis (ME) or chronic fatigue syndrome (CFS)
  2. 1 in 150 suffers from fibromyalgia
  3. 1 in 110 children has autism spectrum disorder
  4. Lyme disease is a fast growing epidemic in the U.S. (Many sufferers go on to develop a chronic illness similar to ME and CFS.)
  5. 225,000 service men of the 600,000 from the 1991 gulf war have a multisymptom illness similar to ME and CFS called Gulf War illness (GWI), including those who did not serve overseas.

Research and Medical Conclusions


  • Abnormal NK cell number and function
  • Inflammatory cytokine profile indicating abnormal levels of inflammation


  • Cognitive impairment
  • Disordered sleep
  • Perceptual and sensory disturbances
  • Postural orthostatic tachycardia syndrome (POTS)
  • Ataxia
  • Seizures
  • Severe headaches
  • Spinal pain

Infectious Signs and Symptoms:

  • Swollen, tender lymph nodes
  • Sore throat
  • Painful muscles, joints, and nerves
  • Increased susceptibility to infection
  • New onset or increased severity of allergies
  • Post-exertional malaise or exercise intolerance (ME and CFS)
  • Loss of previous levels of physical and mental functioning
  • Worsening of symptoms with stress
  • Night sweats
  • Recurrent flu like symptoms
  • Weakness and extreme malaise
  • Abdominal pain and nausea

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